A Case of Autoimmune Hepatitis Complicated by Undiagnosed Factor VII Deficiency: A Pitfall of Coagulopathy.

Abstract

Prothrombin time (PT) is a key parameter for assessing the severity of liver disease. We present the case of a 37-year-old woman with severe acute liver injury due to autoimmune hepatitis. Although prednisolone drastically improved her hepatocyte function, her PT did not recover to the reference range. A review of her medical records revealed that the patient had normal transaminase levels and prolonged PT 2 years previously. Further examinations of her coagulopathy revealed that she had low factor VII activity, suggesting a diagnosis of factor VII deficiency. Our experience suggests that altered coagulopathy should be considered in cases of liver injury with an extraordinary PT.

• Authors: Kotaro Kishimoto, Keisuke Kakisaka, Tamami Abe, Asami Ito, Kenji Yusa, Akiko Suzuki, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Akio Miyasaka, Ayaka Sato, Masao Nishiya, Naoki Yanagawa, Hidekatsu Kuroda, Takayuki Matsumoto
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) (Nov 20 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 37981301 (Publication Type: Journal Article)