Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer's Disease.

Abstract

The interactions of amyloid proteins with membranes have been subject to many experimental and computational studies, as these interactions contribute in part to neurodegenerative diseases. In this review, we report on recent simulations that have focused on the adsorption and insertion modes of amyloid-β and tau proteins in membranes. The atomistic-resolution characterization of the conformational changes of these amyloid proteins upon lipid cell membrane and free lipid interactions is of interest to rationally design drugs targeting transient oligomers in Alzheimer's disease.

• Authors: Phuong H Nguyen, Philippe Derreumaux
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 28 Issue 20 (Oct 13 2023) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 37894559 (Publication Type: Journal Article, Review)

Chemical References

• Amyloid beta-Peptides
• tau Proteins
• Lipids

Topics

• Humans
• Alzheimer Disease (metabolism)
• Amyloid beta-Peptides (metabolism)
• tau Proteins (metabolism)
• Lipids