Therapeutic potential of bixin on inflammation: a mini review.

Abstract

Chronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory signaling pathways are valuable targets for new treatment modalities. Natural products have gained interest as a potential source of bioactive compounds which provide health benefits in combating inflammatory-related diseases. Recent reports have linked the medicinal values of Bixa orellana L. with its anti-inflammatory activities. Therefore, this review aims to examine the therapeutic potential of bixin, a major bioactive constituent found in the seeds of B. orellana, on inflammatory-related diseases based on existing in vitro and in vivo evidence. Additionally, the anti-inflammatory mechanism of bixin via signaling pathways is explored and possible toxic effects are addressed. The findings suggest that bixin may ameliorate inflammation via inhibition of toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and thioredoxin-interacting protein/NOD-like receptor protein 3 (TXNIP/NLRP3) inflammasome mechanisms. More well-planned clinical studies should be performed to verify its effectiveness and safety profile.

• Authors: Saminathan Shadisvaaran, Kok-Yong Chin, Shahida Mohd-Said, Xin-Fang Leong
• Journal: Frontiers in nutrition (Front Nutr) Vol. 10 Pg. 1209248 ( 2023) ISSN: 2296-861X [Print] Switzerland
• PMID: 37781110 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 Shadisvaaran, Chin, Mohd-Said and Leong.