Is there a relationship between response to total sleep deprivation and efficacy of clomipramine treatment in depressed patients?

Abstract

Total sleep deprivation (TSD) and tricyclic medication are successful treatment modalities for patients with a major depressive disorder. Recent studies have suggested a positive relationship between TSD response and succeeding tricyclic treatment, even on a very specific level, thus supporting the assumption of two distinct biochemical subtypes of depression. The present study tested this hypothesis by treating 10 inpatients with a major depressive disorder first with TSD and succeedingly with clomipramine. Contrary to expectation, a negative relationship between clinical response to the two treatment modalities was found.

• Authors: D Höchli, D Riemann, J Zulley, M Berger
• Journal: Acta psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 74 Issue 2 Pg. 190-2 (Aug 1986) ISSN: 0001-690X [Print] United States
• PMID: 3776665 (Publication Type: Journal Article)

Chemical References

• Clomipramine

Topics

• Adolescent
• Adult
• Bipolar Disorder (drug therapy)
• Clomipramine (therapeutic use)
• Depressive Disorder (drug therapy, psychology)
• Humans
• Middle Aged
• Prognosis
• Psychiatric Status Rating Scales