Abstract | BACKGROUND: METHODS: We enrolled 86 patients with clinical stage II-IVA from the Sun Yat-sen University Cancer Center. The patients were divided into two groups: PF group (41) and DP group (45). Statistics were analyzed using SPSS version 19.0. RESULTS: The 5-year OS rates were 62.9% ± 7.6% in PF group, and 52.7% ± 7.5% in DP group (P = 0.131), respectively. The 5-year PFS rates were 43.9% ± 7.8% for PF group, and 40.0% ± 7.3% for DP group (P = 0.398), respectively. Sixteen patients in the DP group and thirteen in the PF group received salvage treatment. For those patients with local residual or local recurrent disease, the median survival time after salvage treatment was 13.5 months and the 1, 2, and 3-year survival rates were 79.0%, 50.3%, and 43.1%, respectively. For all patients, thirteen (15.1%) had Grade 2 late cardiac toxicities. One patient had Grade 2 pleural effusion and required diuretic. Most patients with pneumonia are mild, and only one patient in PF group had Grade 2 pneumonia. One patient in the DP group developed tracheoesophageal fistula. CONCLUSIONS: The 5-year follow-up confirmed that definitive CCRT with the DP regimen did not improve the treatment response, OS, or PFS in patients with ESCC compared to the PF regimen. The PF regimen remains the standard regimen for definitive CCRT for patients with locally advanced ESCC. Long-term follow-up also suggested that appropriate and active salvage treatment has a survival benefit for some patients, and late cardiopulmonary toxicities should be noticed during follow-up. TRIAL REGISTRATION: The trial was registered at https://clinicaltrials.gov (ClinicalTrials.gov Identifier: NCT02969473, October 2010).
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Authors | Hui Jiang, Kanjiebubi Makelike, Baoqing Chen, Mian Xi, Qiaoqiao Li, Yonghong Hu, Yujia Zhu |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 18
Issue 1
Pg. 150
(Sep 12 2023)
ISSN: 1748-717X [Electronic] England |
PMID | 37700348
(Publication Type: Randomized Controlled Trial, Clinical Trial, Phase II, Journal Article)
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Copyright | © 2023. BioMed Central Ltd., part of Springer Nature. |
Chemical References |
- Docetaxel
- Cisplatin
- Fluorouracil
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Topics |
- Humans
- Docetaxel
- Follow-Up Studies
- Esophageal Squamous Cell Carcinoma
(therapy)
- Cisplatin
- Esophageal Neoplasms
(therapy)
- Prospective Studies
- Chemoradiotherapy
- Fluorouracil
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