Determination of homeodomain interacting protein kinase 2 polymorphisms rs2058265, rs6464214, and rs7456421 in patients with kidney stone.

Abstract

OBJECTIVE:

This study aimed to investigate whether homeodomain interacting protein kinase 2 (HIPK2) polymorphism is associated with renal stone formation in a Turkish population.

MATERIALS AND METHODS:

A total of 129 patients with calcium nephrolithiasis and 67 sex- and age-matched healthy controls were enrolled in the study. Blood samples were collected into EDTA tubes. The DNA of patients was extracted using a QIAsymphony® automated DNA isolation system. The Chi-square test was applied in the comparisons between the patient and control groups in respect of the differences in the genotype and allele frequencies.

RESULTS:

No statistically significant difference was found between the groups in terms of single nucleotide polymorphism (SNP) incidence in single allele and double alleles in the rs2058265 and rs6464214 regions (p = 0.13 and 0.37, respectively). The SNP incidence in double alleles in nephrolithiasis patients at rs7456421 was statistically significantly lower than in the control group (p = 0.001).

CONCLUSION:

Distributions of the genotype and allele of the three polymorphisms (rs2058265, rs6464214, and rs745642 in HIPK2) were not associated with an increased risk of kidney stone in this Turkish population.

• Authors: Cavit Ceylan, Omer Gokhan-Doluoglu, Sedat Taştemur, Ibrahim Keleş, Gulay Ceylan, Ahmet Cevdet-Ceylan, Emre Uzun, Eda Tokat
• Journal: Cirugia y cirujanos (Cir Cir) Vol. 91 Issue 4 Pg. 474-478 ( 2023) ISSN: 2444-054X [Electronic] Mexico
• Vernacular Title: Determinación de los polimorfismos rs2058265, rs6464214 y rs7456421 de la proteína cinasa 2 que interactúan con el homeodominio en pacientes con cálculos renales.
• PMID: 37677956 (Publication Type: Journal Article)
• Copyright: Copyright: © 2023 Permanyer.

Chemical References

• HIPK2 protein, human
• Carrier Proteins
• Protein Serine-Threonine Kinases

Topics

• Humans
• Kidney Calculi (genetics)
• Alleles
• Genotype
• Polymorphism, Single Nucleotide
• Carrier Proteins
• Protein Serine-Threonine Kinases (genetics)