Homologous platelet gel on radiation-induced dermatitis in a patient receiving head and neck radiotherapy plus cetuximab: A case report.

Abstract

INTRODUCTION:

Acute radiodermatitis is a significant complication of cancer radiotherapy, and platelet-based therapies are emerging as potential new treatments.

MAIN SYMPTOMS AND IMPORTANT CLINICAL FINDINGS:

In this report, we present the case of a patient with head and neck cancer undergoing radiotherapy combined with the monoclonal antibody cetuximab. After 4 weeks of this treatment, the patient developed cutaneous radiation dermatitis. Despite receiving standard treatment with corticosteroids and emollient cream, the lesion did not improve.

MAIN DIAGNOSIS:

cutaneous radiation dermatitis on head and neck cancer patient.

THERAPEUTIC INTERVENTIONS:

Topical application of platelet gel was initiated on the wound. From the second week of radiotherapy to the 4th week, homologous platelet-rich plasma was applied on the dermatitis using a bandage, 4 times a day.

OUTCOMES:

The topical treatment with homologous platelet gel resulted in complete healing of the radiodermatitis, including restoration of the epidermis, reepithelialization, and reduction in associated pain.

CONCLUSION:

homologous platelet gel might be an alternative to standard treatment of radiation dermatitis.

• Authors: Monica Guberti, Davide Schiroli, Chiara Marraccini, Genny Mazza, Cinzia Iotti, Roberto Baricchi, Barbara Iotti, Lucia Merolle
• Journal: Medicine (Medicine (Baltimore)) Vol. 102 Issue 34 Pg. e34779 (Aug 25 2023) ISSN: 1536-5964 [Electronic] United States
• PMID: 37653754 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Cetuximab
• Antineoplastic Agents, Immunological
• Gels

Topics

• Radiodermatitis (etiology, therapy)
• Cetuximab (therapeutic use)
• Antineoplastic Agents, Immunological (therapeutic use)
• Combined Modality Therapy
• Humans
• Male
• Aged
• Squamous Cell Carcinoma of Head and Neck (drug therapy, radiotherapy)
• Oropharyngeal Neoplasms (drug therapy, radiotherapy)
• Blood Platelets
• Gels
• Complementary Therapies (methods)