Abstract | Background: Aim and Objectives: This study aims to evaluate the short-term effect of partial external biliary diversion (PEBD) on pruritus, liver disease progression, patient's growth, and quality of life. Material and Methods: This prospective cohort study enrolled children with PFIC and AGS from July 2019 to July 2021, whose guardians consented to the PEBD procedure. A standard surgical approach was performed by a single surgeon. Outcomes were measured subjectively and objectively pre- and post-procedure using the pruritus 5-D itching score, Paediatric Quality of Life Inventory scale (PedsQL), growth parameters, bile acids level, and liver function tests. Patients' follow-up period ranged from 6 to 12 months. Results: Seven patients had PEBD procedure; five with PFIC and two with AGS. A significant improvement was detected in the 5-D itching score (p-value < 0.001), PedsQL (p-value < 0.001), and bile acids level (p-value 0.013). The preexisting growth failure was ameliorated. The downward trend in the bilirubin level was not significant. No influential difference in the other liver function tests occurred. No intra-operative complications encountered. Only one case had a post-operative stoma prolapse which was managed surgically. Conclusion: PEBD procedure could be considered as an effective and safe treatment options for intractable pruritus in patients with PFIC or AGS, providing preserved synthetic liver functions.
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Authors | Hadeer Mohamed Nasr El-Din, Noha Adel Yassin, Nehal M El Koofy, Alaa Obeida, Sherif Nabhan Kaddah, Gamal Hassan Eltagy, Wesam Mohamed |
Journal | Journal of Indian Association of Pediatric Surgeons
(J Indian Assoc Pediatr Surg)
2023 Jul-Aug
Vol. 28
Issue 4
Pg. 293-299
ISSN: 0971-9261 [Print] India |
PMID | 37635886
(Publication Type: Journal Article)
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Copyright | Copyright: © 2023 Journal of Indian Association of Pediatric Surgeons. |