Mechanisms of alkaliptosis.

Abstract

Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various treatments exist, including surgery, radiotherapy, chemotherapy, immunotherapy and combination therapies, there remains a need to develop therapies that target regulated cell death pathways to eliminate cancer cells while preserving normal cells. Alkaliptosis, a pH-dependent cell death process triggered by the small molecular compound JTC801, has been identified as a novel approach for malignant tumor treatment, particularly in pancreatic cancer. Two major signaling pathways, the NF-κB-CA9 pathway and the ATP6V0D1-STAT3 pathway, contribute to the induction of alkaliptosis. This review summarizes recent developments in our understanding of alkaliptosis signals, mechanisms, and modulation, and explores its context-dependent effects on drug resistance, inflammation, and immunity. By providing a deeper understanding of the heterogeneity and plasticity of cell death mechanisms, this information holds promise for informing the design of more effective anti-tumor therapies.

• Authors: Fangquan Chen, Rui Kang, Jiao Liu, Daolin Tang
• Journal: Frontiers in cell and developmental biology (Front Cell Dev Biol) Vol. 11 Pg. 1213995 ( 2023) ISSN: 2296-634X [Print] Switzerland
• PMID: 37601110 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 Chen, Kang, Liu and Tang.