Gastric cancer is a common malignant
tumor of the digestive tract, with a low early diagnosis rate. N-methyl-N-nitro-N-
nitroguanidine (
MNNG) is one of the main risk factors for
gastric cancer.
Phytochemicals are healthy active substances derived from vegetables, fruits, nuts,
tea, herbal medicines and other plants. Taking
phytochemicals is a very promising strategy for the prevention and treatment of
gastric cancer. Many studies have proved that
phytochemicals have protective effects on
MNNG induced
gastric cancer via inhibiting cell proliferation, enhancing immunity, suppressing cell invasion and migration, inducing apoptosis and autophagy, blocking angiogenesis, inhibiting Helicobacter pylori
infection as well as regulating metabolism and microbiota. The intervention and
therapeutic effects of
phytochemicals in
MNNG induced
gastric cancer have attracted more and more attention. In order to better study and explore the role, advantages and challenges of
phytochemicals in
MNNG induced
gastric cancer, we summarized the intervention and
therapeutic effects of
phytochemicals in
MNNG induced
gastric cancer. This review may help to further promote the research and clinical application of
phytochemicals in
MNNG induced
gastric cancer, and provide some new insights.