Abstract | INTRODUCTION AND OBJECTIVE: MATERIAL AND METHODS: The study involved two groups of patients diagnosed with paranoid schizophrenia in partial remission who participated in a 3-month structured rehabilitation programme combined with neurofeedback (REH group) and a standard support group (CON group). The following parameters were assessed: BDNF and MMP-9 serum levels, AEPs, QEEGs, and psychopathological symptoms (PANSS). RESULTS: A clinical improvement within the 3-month rehabilitation therapy course was correlated with the increase in BDNF and MMP-9 serum level. Despite the increase in BDNF and MMP-9 during the 3-month rehabilitation therapy, it was not possible to demonstrate any strong and significant correlation between the 2 examined neuropeptides. During the 3-month rehabilitation therapy, the theta waveform share reduction in QEEG, P50 latency reduction and amplitude increase correlated with PANSS Total and MMP-9 results. CONCLUSIONS: All clinical (PANSS Positive, Negative, General, Total) and biochemical results (BDNF, MMP-9) of the REH group changed significantly over the 3-month period. Positive symptoms improved only in the CON group.
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Authors | Renata Markiewicz, Agnieszka Anna Markiewicz-Gospodarek, Beata Dobrowolska, Iwona Bojar, Bartosz Łoza |
Journal | Annals of agricultural and environmental medicine : AAEM
(Ann Agric Environ Med)
Vol. 30
Issue 2
Pg. 315-321
(Jun 26 2023)
ISSN: 1898-2263 [Electronic] Poland |
PMID | 37387382
(Publication Type: Journal Article)
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Chemical References |
- Brain-Derived Neurotrophic Factor
- Matrix Metalloproteinase 9
- MMP9 protein, human
- BDNF protein, human
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Topics |
- Humans
- Brain-Derived Neurotrophic Factor
- Matrix Metalloproteinase 9
- Patients
- Pilot Projects
- Schizophrenia
(therapy)
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