Radiogenomics in NF2-Associated Schwannomatosis (Neurofibromatosis Type II): Exploratory Data Analysis.

Abstract

Our pilot study aimed at exploratory radiogenomic data analysis in patients with NF2-associated schwannomatosis (formerly neurofibromatosis type II) to assume the potential of image biomarkers in this pathology. Fifty-three unrelated patients (37 (69.8%) women, avg. age 30.2 ± 11.2 y.o.) were enrolled in the study. First-order, gray-level co-occurrence matrix (GLCM), gray-level run length matrix (GLRLM), and geometry-based statistics were calculated (3718 features per region of interest). We demonstrated imaging patterns and statistically significant differences in radiomic features potentially related to the genotype and clinical phenotype of the disease. However, the clinical utility of these patterns should be further evaluated. The study was supported by the Russian Science Foundation grant 21-15-00262.

• Authors: Gleb Danilov, Elizaveta Makashova, Mikhail Galkin, Kristina Karandasheva
• Journal: Studies in health technology and informatics (Stud Health Technol Inform) Vol. 305 Pg. 588-591 (Jun 29 2023) ISSN: 1879-8365 [Electronic] Netherlands
• PMID: 37387099 (Publication Type: Journal Article)

Topics

• Female
• Male
• Humans
• Neurofibromatosis 2 (diagnostic imaging, genetics)
• Pilot Projects
• Neurofibromatoses (diagnostic imaging, genetics)
• Data Analysis