Abstract |
In vitro drug testing using (3H) incorporation was utilized for specimens from 60 patients with advanced malignancies, mainly gastrointestinal cancers. Forty-six specimens had sufficient growth for drug testing. Forty-seven percent of stomach cancer specimens and 67% of colorectal cancer specimens demonstrated in vitro chemosensitivity. Among 9 chemotherapeutic agents tested, ara-C, 5-fluorouracil, and mitomycin C had higher percentages of positive sensitivity for stomach cancer, whereas actinomycin D, carboquone, and ACNU had a more pronounced effect on colorectal cancer. A comparison was made between the results of chemosensitivity tests and clinical response. In 46 drug assays, in vitro/in vivo drug responses were correlated in 78% with a true-positive predictive rate of 47% and a true-negative rate of 94%. This test appears to be a reliable indicator for clinical response to the same chemotherapeutic agents in human malignant disease.
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Authors | H Ichihashi |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 13
Issue 4 Pt 2
Pg. 1156-62
(Apr 1986)
ISSN: 0385-0684 [Print] Japan |
PMID | 3729437
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Tritium
- Thymidine
- Uridine
|
Topics |
- Adult
- Aged
- Antineoplastic Agents
(pharmacology)
- Drug Evaluation, Preclinical
(methods)
- Humans
- Middle Aged
- Neoplasms
(drug therapy, metabolism)
- Thymidine
(metabolism)
- Tritium
- Uridine
(metabolism)
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