[Research progress on chemical structures and pharmacological effects of natural cytisine and its derivatives].

Abstract

Cytisine derivatives are a group of alkaloids containing the structural core of cytisine, which are mainly distributed in Fabaceae plants with a wide range of pharmacological activities, such as resisting inflammation, tumors, and viruses, and affecting the central nervous system. At present, a total of 193 natural cytisine and its derivatives have been reported, all of which are derived from L-lysine. In this study, natural cytisine derivatives were classified into eight types, namely cytisine type, sparteine type, albine type, angustifoline type, camoensidine type, cytisine-like type, tsukushinamine type, and lupanacosmine type. This study reviewed the research progress on the structures, plant sources, biosynthesis, and pharmacological activities of alkaloids of various types.

• Authors: Qing-Qing Zhou, Xiao-Yan Xie, Yan-Xia Zhang, Wu Zhou, Zha-Jun Zhan, Jin-Biao Xu
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 48 Issue 10 Pg. 2679-2698 (May 2023) ISSN: 1001-5302 [Print] China
• PMID: 37282929 (Publication Type: English Abstract, Journal Article)

Chemical References

• cytisine
• Alkaloids
• Quinolizines
• Azocines

Topics

• Alkaloids (pharmacology, chemistry)
• Quinolizines (pharmacology)
• Azocines (pharmacology, chemistry)
• Fabaceae