Ulcerative arterial
bleeding is characterized by sudden onset, rapid disease development, and high mortality, which is a great challenge for clinicians to treat, specially
bleeding in areas where endoscopic operation is difficult, or in the case of diffuse
bleeding,
tumor bleeding, and recurrent
bleeding. Herein, we proposed a novel treatment strategy using
biomaterials to protect the
wound and isolate the erosion of digestive tract contents to prevent arterial
bleeding in advance. By introducing
chitosan to construct multihydrogen-bonding and an electrostatic interaction system, we developed
polyethyleneimine/
polyacrylic acid/
chitosan (PEI/PAA/CS) multifunctional
hydrogel. The new
hydrogel is characterized by ultrafast gelation, strong
tissue adhesion, gastric acid resistance, burst resistance, biocompatibility, hemostasis, and tissue repair. The addition of CS significantly improved the
tissue adhesion, biocompatibility, hemostasis, and tissue repair ability of the
hydrogel. The PEI/PAA/CS
hydrogel could adhere to the
ulcer surface and form a protective layer on the
wound to prevent arterial
bleeding. Importantly, the PEI/PAA/CS
hydrogel also has the ability to stop
bleeding and promote
wound repair, which has been demonstrated in a variety of
hemorrhage models in rats and rabbits. All of these factors indicate that the PEI/PAA/CS
hydrogel is a promising
biomaterial for reducing the risk of ulcerative arterial
bleeding.