Abstract | Background:
Ginsenoside F2 (GF2), a minor component of Panax ginseng, has been reported to possess a wide variety of pharmacological activities. However, its effects on glucose metabolism have not yet been reported. Here, we investigated the underlying signaling pathways involved in its effects on hepatic glucose. Methods: HepG2 cells were used to establish insulin-resistant (IR) model and treated with GF2. Cell viability and glucose uptake-related genes were also examined by real-time PCR and immunoblots. Results: Conclusion: Overall, GF2 improved glucose metabolism disorders by reducing cellular oxidative stress in IR-HepG2 cells via MAPK signaling, participating in the PI3K/AKT/GSK-3β signaling pathway, promoting glycogen synthesis, and inhibiting gluconeogenesis.
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Authors | Shengqiang Han, Long You, Yeye Hu, Shuai Wei, Tingwu Liu, Jae Youl Cho, Weicheng Hu |
Journal | Journal of ginseng research
(J Ginseng Res)
Vol. 47
Issue 3
Pg. 420-428
(May 2023)
ISSN: 1226-8453 [Print] Korea (South) |
PMID | 37252284
(Publication Type: Journal Article)
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Copyright | © 2023 The Korean Society of Ginseng. Publishing services by Elsevier B.V. |