Abstract | OBJECTIVES: METHODS: We measured LCN2 levels in serum samples from SLE pregnancies (n=25) at seven different time points. Samples were taken preconception, in each trimester, at 6 weeks, 6 months and 12 months postpartum. Serum LCN2 levels were compared to samples from rheumatoid arthritis (RA) (n=27) and healthy (n=18) pregnancies at each time point using t-test, and for all time points using a linear mixed effects model. In addition, we investigated the association between LCN2 levels and disease activity, CRP, kidney function, BMI, treatment regimen and adverse pregnancy outcome for SLE and RA patients. RESULTS: We found significantly lower serum LCN2 levels throughout pregnancy in SLE patients with quiescent disease compared to RA and healthy pregnancies. We did not find an association between serum LCN2 and disease activity or adverse pregnancy outcome in SLE pregnancies. CONCLUSIONS: In a population of SLE women with low disease activity we have not found evidence that serum LCN2 levels predict disease activity or adverse pregnancy outcomes. Further studies are needed to elucidate a possible biological role of low LCN2 levels in SLE pregnancies.
|
Authors | Tina Therese Pedersen, Mona H Fenstad, Marianne Wallenius, Elisabeth Hetlelid, Turid Follestad, Mette Langaas, Markus Haug |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
Vol. 41
Issue 9
Pg. 1838-1846
(Sep 2023)
ISSN: 0392-856X [Print] Italy |
PMID | 37246773
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Pregnancy
- Female
- Humans
- Pregnant Women
- Lipocalin-2
- Pregnancy Outcome
(epidemiology)
- Lupus Erythematosus, Systemic
(complications)
- Pregnancy Complications
- Arthritis, Rheumatoid
(complications)
- Biomarkers
- Retrospective Studies
|