Abstract |
We report the clinical course of 35 patients with Parkinson's disease who experienced an initially favorable response to pergolide and who were taking the drug for at least 6 months. The duration of pergolide treatment was 6-50 (25 +/- 16 SD) months. Of the 14 patients who remained on pergolide for over 2 years, 12 remained less disabled for 26 +/- 17 SD months, seven enjoyed increased "on" time for 39 +/- 8 SD months, and nine had a lower Hoehn-Yahr stage for 25 +/- 17 SD months. Pergolide was discontinued after 5-39 months in eight patients; six patients then deteriorated. Pergolide can remain efficacious in the treatment of Parkinson's disease for up to 50 months.
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Authors | J I Sage, R C Duvoisin |
Journal | Clinical neuropharmacology
(Clin Neuropharmacol)
Vol. 9
Issue 2
Pg. 160-4
( 1986)
ISSN: 0362-5664 [Print] United States |
PMID | 3708601
(Publication Type: Journal Article)
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Chemical References |
- Antiparkinson Agents
- Ergolines
- Pergolide
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Topics |
- Aged
- Antiparkinson Agents
(adverse effects, therapeutic use)
- Ergolines
(adverse effects, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Parkinson Disease
(drug therapy, physiopathology)
- Pergolide
- Time Factors
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