Abstract | OBJECTIVES: METHODS: For patients with NSCLC whose tumor tissues could not be used to detect oncogenic driver gene status, molecular mutation status in 101 MPE cell blocks was tested using amplification refractory mutation system polymerase chain reaction prior to treatment. Corresponding targeted therapies were adopted based on the detection results. RESULTS: Mutations observed in MPE cell blocks included epidermal growth factor receptor mutation (EGFR) (60.4% [61/101]), anaplastic lymphoma kinase fusion (6.3% [5/80]), and ROS proto-oncogene 1 receptor tyrosine kinase fusion (3% [2/70]). Other mutations that were found in <5% of patients included epidermal growth factor receptor-2, rat sarcoma-filtered germ carcinogenic homologous B1, neuroblastoma RAS viral oncogene homolog, and mesenchymal epithelial transition factor exon 14. The median follow-up time was 23.5 months for the 41 patients with a single EGFR mutation and who received tyrosine kinase inhibitor monotherapy as the first-line treatment; in these patients, the objective response rate was 78% (95% confidence intervals (CI), 62% to 89%), progression-free survival was 10.8 months (95% CI, 8.7 to 13.0 months), and overall survival was 31.7 months (95% CI, 13.9 to 49.4 months). CONCLUSIONS:
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Authors | Rixu Lin, Yida Li, Yi Lin, Wenyi Tian, Lei Jiang, Jianmin Li |
Journal | Diagnostic cytopathology
(Diagn Cytopathol)
Vol. 51
Issue 7
Pg. 397-405
(Jul 2023)
ISSN: 1097-0339 [Electronic] United States |
PMID | 37078537
(Publication Type: Journal Article)
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Copyright | © 2023 Wiley Periodicals LLC. |
Chemical References |
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Topics |
- Humans
- Carcinoma, Non-Small-Cell Lung
(drug therapy, genetics, diagnosis)
- Lung Neoplasms
(drug therapy, genetics, metabolism)
- Pleural Effusion, Malignant
(drug therapy, genetics, diagnosis)
- ErbB Receptors
(genetics)
- Molecular Diagnostic Techniques
- Mutation
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