Local hyperthermia treatment, a common
immunoadjuvant therapy, has been used in treating various human papillomavirus (HPV)
infections. For multiple
warts, it can clear off all
warts of the body through targeted irradiation on one
wart. We reported a case of a 22-year-old patient with multiple plantar
warts combined with periungual
warts, in which previous treatments were ineffective. Therefore, we utilized
local hyperthermia treatment at 44°C using the largest fused-
wart plaque on the right plantar as the treatment target for 30-minute irradiation each time. The
hyperthermia induction
therapy was performed on day 1, 2, 3, 12 and 13, followed by weekly maintenance
therapy for 6 times. After 2 months of treatment, both irradiated and non-irradiated lesions disappeared, and no recurrence occurred during the follow-up period. This case indicates that
local hyperthermia treatment may be a safe and effective approach for patients with multiple, recalcitrant, and site-specific viral
warts due to the ineffectiveness of conventional treatment.