Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury in mice.

Abstract

INTRODUCTION:

Cordycepin has been reported to exhibit hepatic protective and anti-inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)-induced liver injury in a mouse model.

METHODS:

Mice were pretreated with cordycepin by gavage for 3 weeks, followed by the establishment of the IR modeling. Liver injury, Suzuki's histological grading, hepatic apoptosis, and inflammatory responses were evaluated by biochemical and pathological analysis.

RESULTS:

It was found that Cordycepin pretreatment at 50 mg/kg for 3 weeks attenuated IR-induced liver injury, as reflected by the significant decrease of the levels of aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, and low-density lipoprotein. Cordycepin pretreatment also reduced histopathological changes, attenuated hepatocyte apoptosis, inflammatory responses in the livers of IR mice. Mechanically, toll-like receptor 4/nuclear factor kappa-B signaling in liver tissues was inhibited by Cordycepin pretreatment.

CONCLUSIONS:

In conclusion, Cordycepin pretreatment protects IR-induced liver injury, which demonstrates its potential for the treatment of IR in the liver.

• Authors: Yunxia Liu, Mingwei Sheng, Lili Jia, Min Zhu, Wenli Yu
• Journal: Immunity, inflammation and disease (Immun Inflamm Dis) Vol. 11 Issue 3 Pg. e792 (03 2023) ISSN: 2050-4527 [Electronic] England
• PMID: 36988254 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

Chemical References

• cordycepin

Topics

• Mice
• Animals
• Chemical and Drug Induced Liver Injury, Chronic
• Reperfusion Injury (prevention & control, pathology)
• Ischemia