Abstract | BACKGROUND: METHODS: The PubMed (https://pubmed.ncbi.nlm.nih.gov/) and EMBASE databases (https://www.embase.com/) were searched for the terms " Parkinson Disease" and " camptocormia" in combination with " deep brain stimulation". We then explored the efficacy of DBS for camptocormia by statistical analysis of the bending angle, the Unified Parkinson's Disease Rating Scale III (UPDRS-III) and L-dopa equivalent daily dose (LEDD), and by evaluating the prognosis after DBS. RESULTS: Twenty articles that reported results for 152 patients were included in this review. These comprised 136 patients from 16 studies who underwent subthalamic nucleus deep brain stimulation (STN-DBS), and 13 patients from 3 studies who underwent globus pallidus internus deep brain stimulation (GPi-DBS). One study used both STN-DBS (2 patients) and GPi-DBS (one patient). After 3-21 months of follow-up, the mean bending angle during the Off-period was significantly reduced compared to pre-DBS (31.5 ± 21.4 vs. 53.6 ± 22.7, respectively; p < 0.0001). For the STN-DBS trials, the mean post-operative bending angles during both Off- and On-periods were significantly reduced compared to pre-operative (32.1 ± 22.7 vs. 55.4 ± 24.1, p = 0.0003; and 33.1 ± 21.5 vs. 43.7 ± 20.6, p = 0.0003, respectively). For GPi-DBS, the mean bending angle post-DBS during the Off-period was considerably lower than pre-DBS (28.5 ± 10.7 vs. 42.9 ± 9.9, p < 0.001). The decrease in bending angle after DBS was negatively correlated with the duration of camptocormia (R = - 0.433, p = 0.013), whereas positively associated with the pre-bending angle (R = 0.352, p = 0.03). CONCLUSIONS: DBS is an effective treatment for camptocormia in PD. Patients in the early stage of camptocormia with more significant bending angle may benefit more from DBS.
|
Authors | Fuli Wang, Lili He, Hecong Zhao, Xiaoyan Guo |
Journal | Journal of integrative neuroscience
(J Integr Neurosci)
Vol. 22
Issue 1
Pg. 11
(Jan 05 2023)
ISSN: 0219-6352 [Print] Singapore |
PMID | 36722246
(Publication Type: Meta-Analysis, Systematic Review)
|
Copyright | © 2023 The Author(s). Published by IMR Press. |
Chemical References |
|
Topics |
- Humans
- Parkinson Disease
(complications, therapy)
- Levodopa
- Databases, Factual
- Mental Status and Dementia Tests
- Subthalamic Nucleus
|