[Pharmacological analysis of the participation of ethanol-oxidizing enzyme systems in ethanol metabolism at different stages of experimental alcoholism].

Abstract

Using head space chromatography, the pharmacological analysis of changes in the activity of ethanol-oxidizing enzymatic systems: alcohol dehydrogenase, catalase, microsomal ethanol-oxidizing system under the effect of pyrazole and aminotriazole, has been performed on the model of experimental alcoholism in rats. It was shown that the rate of ethanol elimination from the rats' blood at all stages of experimental alcoholism was determined by alcohol dehydrogenase, while catalase and microsomal ethanol-oxidizing system activities did not play an important role.

• Authors: N V Vlasova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 104 Issue 9 Pg. 323-5 (Sep 1987) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Farmakologicheskiĭ analiz uchastiia otdel'nykh étanolokisliaiushchikh fermentnykh sistem v metabolizme étanola na raznykh stadiiakh éksperimental'nogo alkogolizma.
• PMID: 3663920 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ethanol
• Alcohol Dehydrogenase
• Catalase

Topics

• Alcohol Dehydrogenase (metabolism)
• Alcoholism (metabolism)
• Animals
• Catalase (metabolism)
• Ethanol (metabolism)
• Male
• Rats