Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells.

Abstract

Excessive glutamate can cause oxidative stress in neuronal cells and this can significantly contribute to the etiology of neurodegenerative disease. The present study mainly aims to investigate that aloe extract (AE) and fermented aloe extract (FAE) could protect against glutamate-induced cytotoxicity by modulating oxidative stress. In this study, both AE and FAE showed potent neuroprotective activity by inhibiting ROS and Ca2+ concentration, increasing mitochondria membrane potential, and activating glutathione-related enzymes against glutamate-insulted neurotoxicity in HT22 cells. In addition, the neuroprotective activity of FAE was more potent than that of AE. HPLC analysis reveals that the chemical composition of FAE is different from that of AE. Especially, the contents of aloin A, aloin B and aloenin were higher in FAE than in AE. In conclusion, this study indicates that both AE and FAE may have effective neuroprotective activity in glutamate-insulted pathological conditions such as Alzheimer's disease by managing oxidative stress.

• Authors: Ki Beom Jeon, Seong Hun Lee, Yong Seong Kwon, Jin Hong Beak, Hyeon Lee, Choong Je Ma
• Journal: Animal cells and systems (Anim Cells Syst (Seoul)) Vol. 26 Issue 6 Pg. 318-327 ( 2022) ISSN: 1976-8354 [Print] England
• PMID: 36605589 (Publication Type: Journal Article)
• Copyright: © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.