Abstract | OBJECTIVE: DESIGN, SETTING AND PARTICIPANTS: A retrospective cohort study of 496 adult patients (≥18 years of age) diagnosed with PE who were evaluated by the PE response team at a tertiary academic referral centre in the USA. We collected baseline characteristics, laboratory, radiographic and outcome data. Statistical analysis was performed by Student's t-test, Mann-Whitney U test, Fischer's exact or χ2 test where appropriate. Multivariate logistic regression was used to evaluate potential risk factors for pulmonary infarction. RESULTS: We identified 143 (29%) cases of pulmonary infarction in 496 patients with PE. Patients with infarction were significantly younger (52±15.9 vs 61±16.6 years, p<0.001) and with fewer comorbidities. Most infarctions occurred in the lower lobes (60%) and involved a single lobe (64%). The presence of right ventricular (RV) strain on CT imaging was significantly more common in patients with infarction (21% vs 14%, p=0.031). There was no significant difference in advanced reperfusion therapy, in-hospital mortality, length of stay and readmissions between groups. In multivariate analysis, age and evidence of RV strain on CT and haemoptysis increased the risk of infarction. CONCLUSIONS: Radiographic evidence of pulmonary infarction was demonstrated in nearly one-third of patients with acute PE. There was no difference in the rate of reperfusion therapies and the presence of infarction did not correlate with poorer outcomes.
|
Authors | Ka U Lio, Oisin O'Corragain, Riyaz Bashir, Shari Brosnahan, Gary Cohen, Vladimir Lakhter, Joseph Panaro, Belinda Rivera-Lebron, Parth Rali |
Journal | BMJ open
(BMJ Open)
Vol. 12
Issue 12
Pg. e067579
(12 29 2022)
ISSN: 2044-6055 [Electronic] England |
PMID | 36581412
(Publication Type: Observational Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Topics |
- Adult
- Humans
- Pulmonary Infarction
- Retrospective Studies
- Pulmonary Embolism
(complications, diagnostic imaging, epidemiology)
- Lung
- Risk Factors
- Acute Disease
- Ventricular Dysfunction, Right
|