Ozone therapy for skin diseases: Cellular and molecular mechanisms.

Abstract

Ozone is a highly reactive oxidant molecule consisting of triatomic oxygen atoms. Ozone therapy can be achieved using ozonated hydrotherapy, ozonated oil, ozone autohemotherapy, and other innovative dosage forms of ozone products. Ozone is frequently used as a complementary therapy for various cutaneous diseases, including infectious skin diseases, wound healing, eczema, dermatitis, psoriasis, axillary osmidrosis, diabetic foot, and pressure ulcers. In addition, several studies have reported the superior potential of ozone therapy for improving skin and gut microbiomes, as well as antitumour and antiaging treatment. Ozone therapy is an emerging treatment strategy that acts via complex mechanisms, including antioxidant effects, immunomodulatory capacity, and modulation of local microcirculation. Studies assessing the mechanism of ozone have gradually expanded in recent years. This review article aims to summarise and explore the possible molecular biological mechanisms of ozone in cutaneous diseases and provide compelling theoretical evidence for the application of ozone in cutaneous diseases.

• Authors: Liyao Liu, Liyue Zeng, Lihua Gao, Jinrong Zeng, Jianyun Lu
• Journal: International wound journal (Int Wound J) Vol. 20 Issue 6 Pg. 2376-2385 (Aug 2023) ISSN: 1742-481X [Electronic] England
• PMID: 36527235 (Publication Type: Journal Article, Review)
• Copyright: © 2022 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.

Chemical References

• Ozone

Topics

• Humans
• Skin Diseases (drug therapy)
• Skin
• Ozone (therapeutic use)
• Wound Healing
• Skin Diseases, Infectious