Abstract | PURPOSE OF THE REVIEW: RECENT FINDINGS: Emerging data suggest that Treg deficiencies are disease-specific, affecting distinct pathways in distinct vasculitides. Decreased peripheral blood frequencies of Treg are described in all vasculitis when compared to healthy donors. Altered Treg functions are reported in GCA, Takayasu arteritis, AAV, and Behçet's disease with different mechanisms proposed. Treatment with biologics, and sometimes other immunosuppressants, may restore Treg frequencies and/or immune activity with significant differences in active disease or disease in remission in several systemic vasculitis. IL-10 is elevated in GCA, AAV, cryoglobulinemia associated vasculitis. In Behçet's disease, IL-10 is decreased in peripheral blood and elevated in saliva. In Takayasu arteritis, IL-10 levels were essentially elevated in patients' vessel wall. Several new therapeutic approaches targeting Treg and Il-10 (low dose IL-2, CAR Treg…) are developed to treat patients with systemic vasculitis. SUMMARY:
|
Authors | Adrien Mirouse, Patrice Cacoub, David Saadoun |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 35
Issue 1
Pg. 25-30
(01 01 2023)
ISSN: 1531-6963 [Electronic] United States |
PMID | 36508306
(Publication Type: Systematic Review, Journal Article)
|
Copyright | Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
|
Topics |
- Humans
- T-Lymphocytes, Regulatory
- Interleukin-10
(therapeutic use)
- Behcet Syndrome
- Giant Cell Arteritis
(drug therapy)
- Takayasu Arteritis
(drug therapy)
- Systemic Vasculitis
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
(therapy)
|