Abstract | PURPOSE: Meta-[18F]fluorobenzylguanidine ([ 18F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [ 18F]mFBG PET-CT for imaging in neuroblastoma. METHODS: In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta-[123I]iodobenzylguanidine ([123I] mIBG) scanning, consisting of total body planar scintigraphy in combination with single-photon emission computed tomography-CT (SPECT-CT). Within two weeks of [123I] mIBG scanning, total body PET-CTs were performed at 1 h and 2 h after injection of [ 18F]mFBG (2 MBq/kg). Detected tumour localisations on scan pairs were compared. Soft tissue disease was quantified by number of lesions and skeletal disease by SIOPEN score. RESULTS: Twenty paired [123I] mIBG and [ 18F]mFBG scans were performed in 14 patients (median age 4.9 years, n = 13 stage 4 disease and n = 1 stage 4S). [ 18F]mFBG injection was well tolerated and no related adverse events occurred in any of the patients. Mean scan time for [ 18F]mFBG PET-CT (9.0 min, SD 1.9) was significantly shorter than for [123I] mIBG scanning (84.5 min, SD 10.5), p < 0.01. Most tumour localisations were detected on the 1 h versus 2 h post-injection [ 18F]mFBG PET-CT. Compared to [123I] mIBG scanning, [ 18F]mFBG PET-CT detected a higher, equal, and lower number of soft tissue lesions in 40%, 55%, and 5% of scan pairs, respectively, and a higher, equal, and lower SIOPEN score in 55%, 30%, and 15% of scan pairs, respectively. On average, two more soft tissue lesions and a 6-point higher SIOPEN score were detected per patient on [ 18F]mFBG PET-CT compared to [123I] mIBG scanning. CONCLUSION: TRIAL REGISTRATION: Dutch Trial Register NL8152.
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Authors | Atia Samim, Thomas Blom, Alex J Poot, Albert D Windhorst, Marta Fiocco, Nelleke Tolboom, Arthur J A T Braat, Sebastiaan L Meyer Viol, Rob van Rooij, Max M van Noesel, Marnix G E H Lam, Godelieve A M Tytgat, Bart de Keizer |
Journal | European journal of nuclear medicine and molecular imaging
(Eur J Nucl Med Mol Imaging)
Vol. 50
Issue 4
Pg. 1146-1157
(03 2023)
ISSN: 1619-7089 [Electronic] Germany |
PMID | 36504277
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2022. The Authors. |
Chemical References |
- 3-Iodobenzylguanidine
- Iodine-123
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Topics |
- Child, Preschool
- Humans
- 3-Iodobenzylguanidine
- Neuroblastoma
(diagnostic imaging, pathology)
- Pilot Projects
- Positron Emission Tomography Computed Tomography
- Positron-Emission Tomography
(methods)
- Prospective Studies
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