Relationship between Systemic Immune-inflammation Index and Mortality in Intensive Care Patients Diagnosed with Crimean-Congo Hemorrhagic Fever.

Abstract

OBJECTIVE:

To evaluate the power of the systemic immune-inflammation index in the prediction of mortality in severe Crimean-Congo hemorrhagic fever patients.

STUDY DESIGN:

Observational study.

PLACE AND DURATION OF STUDY:

Department of Anaesthesiology and Reanimation, Sivas Cumhuriyet University, Sivas, Turkey, from January to June 2022.

METHODOLOGY:

Intensive care patients diagnosed with Crimean-Congo hemorrhagic fever, between January 2012 and January 2022, were included. Demographic data, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index were recorded. Receiver operating characteristic analysis, Cox regression analysis and Kaplan-Meier mortality analyses were done.

RESULTS:

A cut-off value <1.85 for neutrophil to lymphocyte ratio showed 41.67% sensitivity and 97.06% specificity. A cut-off value <80.75 for the systemic immune-inflammation index showed 84.72% sensitivity and 76.47% specificity. A cut-off value <37.86 for platelet-to- lymphocyte ratio showed 84.72% sensitivity and 73.53% specificity. In patients with systemic immune-inflammation index value <80.75, the mortality rate increased 2.549 times and 3.732 times in patients with a platelet-to-lymphocyte ratio value <37.86.

CONCLUSION:

Similar sensitivity and specificity levels were found for systemic immune-inflammation index and platel-to-lymphocyte ratio regarding the mortality prediction power and impact on mortality. Both tests can be used for the prediction of mortality during the hemorrhagic period in patients with severe Crimean-Congo Hemorrhagic Fever.

KEY WORDS:

Crimean-congo hemorrhagic fever, Systemic immune inflammation index, Mortality, Platelet-to-lymphocyte ratio.

• Authors: Oguz Gundogdu, Onur Avci
• Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 32 Issue 12 Pg. 1538-1543 (Dec 2022) ISSN: 1681-7168 [Electronic] Pakistan
• PMID: 36474371 (Publication Type: Observational Study, Journal Article)

Topics

• Humans
• Hemorrhagic Fever, Crimean (diagnosis)
• Turkey (epidemiology)
• Universities
• Critical Care