A comprehensive review of emodin in fibrosis treatment.

Abstract	Emodin is the main pharmacodynamic components of rhubarb, with significant pharmacological effects and clinical efficacy.Emodin has a variety of therapy effects, such as anti-cancer, anti-fibrosis effects, and is widely used to treat encephalitis, diabetic cataract and organ fibrosis. Several studies have shown that emodin has a good treatment effect on organ fibrosis, but the mechanism is complex. Moreover, the evidence of some studies is conflicting and confusing. This paper reviewed the mechanism, pharmacokinetics and toxicology of emodin in fibrosis treatment, and briefly discussed relevant cutting-edge new formulations to improve the efficacy, the result can provide some reference for future study.
Authors	HaoShang, Xinhua Jia, Huaman Liu, Xinyue Zhang, Yumeng Shao
Journal	Fitoterapia (Fitoterapia) Vol. 165 Pg. 105358 (Mar 2023) ISSN: 1873-6971 [Electronic] Netherlands
PMID	36436587 (Publication Type: Journal Article, Review)
Copyright	Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
Chemical References	Emodin Anthraquinones Plant Extracts
Topics	Rats Animals Emodin (pharmacokinetics) Anthraquinones (pharmacology) Rats, Sprague-Dawley Molecular Structure Plant Extracts (pharmacology) Rheum

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