Surgical Resection for Local and Lateral Lymph Node Recurrence of MSI-high Cecal Cancer with the BRAF V600E Mutation.

Abstract

An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation.

• Authors: Fuminori Teraishi, Atsushi Jikuhara, Ryunosuke Ogawa, Toshiyoshi Fujiwara
• Journal: Acta medica Okayama (Acta Med Okayama) Vol. 76 Issue 5 Pg. 605-608 (Oct 2022) ISSN: 0386-300X [Print] Japan
• PMID: 36352809 (Publication Type: Case Reports)

Chemical References

• Proto-Oncogene Proteins B-raf
• BRAF protein, human

Topics

• Female
• Humans
• Aged, 80 and over
• Microsatellite Instability
• Proto-Oncogene Proteins B-raf (genetics)
• Colorectal Neoplasms (pathology)
• Prognosis
• Mutation
• Cecal Neoplasms (genetics, surgery)
• Lymph Nodes (pathology)