Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art.

Abstract

Breast cancer is the most common type of cancer in women and is the second leading cause of cancer-related deaths worldwide. Early diagnosis and effective therapeutic interventions are critical determinants that can improve survival and quality of life in breast cancer patients. Nanotheranostics are emerging interventions that offer the dual benefit of in vivo diagnosis and therapeutics through a single nano-sized carrier. Rare earth metal-doped upconversion nanoparticles (UCNPs) with their ability to convert near-infrared light to visible light or UV light in vivo settings have gained special attraction due to their unique luminescence and tumor-targeting properties. In this review, we have discussed applications of UCNPs in drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and tumor targeting in breast cancer. Further, present challenges and future opportunities for UCNPs in breast cancer treatment have also been mentioned.

• Authors: Pavan Kumar Chintamaneni, Dasari Nagasen, Katta Chanti Babu, Atul Mourya, Jitender Madan, Dadi A Srinivasarao, R K Ramachandra, P Madhuri Santhoshi, Sai Kiran S S Pindiprolu
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 352 Pg. 652-672 (12 2022) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 36328078 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Topics

• Humans
• Female
• Breast Neoplasms (diagnostic imaging, therapy)
• Quality of Life
• Photochemotherapy
• Nanoparticles (therapeutic use)
• Infrared Rays