Abstract | BACKGROUND: METHODS: Sixty-four ischemic stroke patients were included in the prospective study. Group I consisted of 33 patients with a preserved physiological dipping effect (DIP), while group II included 31 patients with the nondipping phenomenon (NDIP). All subjects had FA gas chromatography and inflammatory metabolite measurements performed with the use of liquid chromatography, their 24 h blood pressure was recorded, and they were assessed with the Epworth sleepiness scale (ESS). RESULTS: In the nondipping group a higher level of C16:0 palmitic acid was observed, while lower levels were observed in regard to C20:0 arachidic acid, C22:0 behenic acid and C24:1 nervonic acid. A decreased leukotriene B4 level was recorded in the nondipping group. None of the FAs and derivatives correlated with the ESS scale in the group of patients after stroke. Correlations were observed after dividing into the DIP and NDIP groups. In the DIP group, a higher score of ESS was correlated with numerous FAs and derivatives. Inflammation of a lower degree and a higher level of anti-inflammatory mediators from EPA and DHA acids favored the occurrence of the DIP. A high level of C18: 3n6 gamma linoleic acid indicating advanced inflammation, intensified the NDIP effect. CONCLUSIONS:
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Authors | Arleta Drozd, Dariusz Kotlęga, Przemysław Nowacki, Sylwester Ciećwież, Tomasz Trochanowski, Małgorzata Szczuko |
Journal | Biomedicines
(Biomedicines)
Vol. 10
Issue 9
(Sep 06 2022)
ISSN: 2227-9059 [Print] Switzerland |
PMID | 36140306
(Publication Type: Journal Article)
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