Potential mouse models of coronavirus-related immune injury.

Abstract

Basic research for prevention and treatment of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues worldwide. In particular, multiple newly reported cases of autoimmune-related diseases after COVID-19 require further research on coronavirus-related immune injury. However, owing to the strong infectivity of SARS-CoV-2 and the high mortality rate, it is difficult to perform relevant research in humans. Here, we reviewed animal models, specifically mice with coronavirus-related immune disorders and immune damage, considering aspects of coronavirus replacement, viral modification, spike protein, and gene fragments. The evaluation of mouse models of coronavirus-related immune injury may help establish a standardised animal model that could be employed in various areas of research, such as disease occurrence and development processes, vaccine effectiveness assessment, and treatments for coronavirus-related immune disorders. COVID-19 is a complex disease and animal models cannot comprehensively summarise the disease process. The application of genetic technology may change this status.

• Authors: Fu-Yao Nan, Cai-Jun Wu, Jia-Hui Su, Lin-Qin Ma
• Journal: Frontiers in immunology (Front Immunol) Vol. 13 Pg. 943783 ( 2022) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 36119040 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Nan, Wu, Su and Ma.

Chemical References

• Spike Glycoprotein, Coronavirus
• spike protein, SARS-CoV-2

Topics

• Animals
• COVID-19
• Disease Models, Animal
• Humans
• Mice
• SARS-CoV-2
• Spike Glycoprotein, Coronavirus