Cerebellar metabolism of phosphatidylethanolamine and its water-soluble precursors during bicuculline-induced convulsive seizures.

Abstract

The incorporation of labeled ethanolamine into phosphatidylethanolamine (PE) and its water-soluble precursors, phosphoethanolamine and CDP-ethanolamine, is measured in rat cerebella during the course of bicuculline-induced convulsive seizures. The labeling of CDP-ethanolamine and phosphoethanolamine diminishes 6 min after the administration of both bicuculline and radioactive ethanolamine whereas that of PE is unaffected in these conditions. Time is very important to this effect; indeed, no differences of the labeling of PE water-soluble precursors can be found in rat cerebellum of normal and convulsing animals 12 min after the administration. The cerebellar pool of CDP-ethanolamine doubles after 6 min of convulsions, which means that unlabeled CDP-ethanolamine forms from a non-radioactive source, such as lipid, may be through the reversal of the ethanolamine phosphotransferase reaction. This effect disappears 12 min after the injection of the convulsant.

• Authors: N Marku, L Corazzi, G L Piccinin, G Arienti
• Journal: Neurochemical research (Neurochem Res) Vol. 12 Issue 4 Pg. 341-4 (Apr 1987) ISSN: 0364-3190 [Print] United States
• PMID: 3600961 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ethanolamines
• Phosphatidylethanolamines
• CDP ethanolamine
• Cytidine Diphosphate
• phosphorylethanolamine
• Bicuculline

Topics

• Animals
• Bicuculline (pharmacology)
• Cerebellum (metabolism)
• Cytidine Diphosphate (analogs & derivatives, metabolism)
• Ethanolamines (metabolism)
• Female
• Phosphatidylethanolamines (metabolism)
• Rats
• Rats, Inbred Strains
• Seizures (chemically induced, metabolism)