Abstract | INTRODUCTION: The introduction of BRAF/ MEK inhibitors has significantly improved overall survival of patients with BRAF V600-mutant advanced or metastatic melanoma. Most patients treated with BRAF/ MEK inhibitors will experience adverse events during the course of their treatment. Kidney impairment, however, was rarely reported in the pivotal trials. To date, there are only three cases of biopsy-proven acute interstitial nephritis associated with dabrafenib and trametinib reported in the literature. CASE REPORT: MANAGEMENT & OUTCOME: DISCUSSION: We report the first case of biopsy-proven interstitial nephritis in a patient treated with dabrafenib and trametinib, with successful introduction of another BRAF/ MEK inhibitor combination. Although rare, clinicians should be aware of the risk of renal adverse events associated with BRAF/ MEK inhibitors. Renal biopsy is mandatory in the absence of a clear explanation or rapid recovery of renal failure. In case of proven interstitial nephritis, corticosteroids should be initiated. Switching to another BRAF/ MEK inhibitor combination can be considered for patients with complete recovery of renal function and limited treatment options.
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Authors | Lore De Ryck, Sigurd Delanghe, Celine Jacobs, Sharareh Fadaei, Lieve Brochez, Michael Saerens |
Journal | Acta clinica Belgica
(Acta Clin Belg)
Vol. 78
Issue 3
Pg. 215-222
(Jun 2023)
ISSN: 2295-3337 [Electronic] England |
PMID | 35996969
(Publication Type: Case Reports, Review, Journal Article)
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Chemical References |
- dabrafenib
- Proto-Oncogene Proteins B-raf
- Protein Kinase Inhibitors
- Mitogen-Activated Protein Kinase Kinases
- BRAF protein, human
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Topics |
- Male
- Humans
- Middle Aged
- Skin Neoplasms
(pathology)
- Proto-Oncogene Proteins B-raf
- Melanoma
(drug therapy, pathology)
- Nephritis, Interstitial
(chemically induced, drug therapy)
- Protein Kinase Inhibitors
(adverse effects)
- Renal Insufficiency
- Mitogen-Activated Protein Kinase Kinases
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
- Mutation
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