Folate-Targeted Curcumin-Loaded Niosomes for Site-Specific Delivery in Breast Cancer Treatment: In Silico and In Vitro Study.
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| Abstract |
As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were higher compared to free drug and Nio-Cur. With PEG-FA-decorated Nio-Cur, levels of Bcl2 were lower than the free drug and Nio-Cur. When MCF7 and 4T1 cell uptake tests of PEG-FA@Nio-Cur and Nio-Cur were investigated, the results showed that the PEG-FA-modified niosomes exhibited the most preponderant endocytosis. In vitro experiments demonstrate that PEG-FA@Nio-Cur is a promising strategy for the delivery of Cur in breast cancer therapy. Breast cancer cells absorbed the prepared nanoformulations and exhibited sustained drug release characteristics.
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| Authors | Banafsheh Honarvari, Sara Karimifard, Niyayesh Akhtari, Mehrnoush Mehrarya, Zahra Salehi Moghaddam, Mohammad Javed Ansari, Abduladheem Turki Jalil, Adrián Matencio, Francesco Trotta, Faten Eshrati Yeganeh, Bahareh Farasati Far, Mandana Kazem Arki, Mohammad Reza Naimi-Jamal, Hassan Noorbazargan, Zahra Asghari Lalami, Mohsen Chiani |
| Journal | Molecules (Basel, Switzerland) (Molecules) Vol. 27 Issue 14 (Jul 20 2022) ISSN: 1420-3049 [Electronic] Switzerland |
| PMID | 35889513 (Publication Type: Journal Article) |
| Chemical References |
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