Rabies in kudu: Revisited.

Abstract

Rabies infects all mammals; however, transmission cycles are only maintained in certain bat and carnivore species. The high incidence of rabies in Greater Kudu (Tragelaphus strepsiceros) observed in Namibia for over 40 years has led to postulation that independent virus transmission is occurring within this antelope population. We have analysed extensive experimental, epidemiological, phylogeographic and deep sequence data, which collectively refute maintenance of an independent rabies cycle in kudu. As rabies in kudu continues to have a negative impact on the Namibian agricultural sector, measures to protect kudu have been investigated, including the use of a third-generation oral rabies vaccine. Initial results show protection of kudu from rabies infection via the oral route, with an appropriate bait design, different application schedules and vaccination doses further enhancing the immune response. Rabies in kudu is a complex interplay at the wildlife-livestock interface and requires a concerted approach to successfully control.

• Authors: Thomas Müller, Rainer Hassel, Mark Jago, Siegfried Khaiseb, Jolandie van der Westhuizen, Adriaan Vos, Sten Calvelage, Susanne Fischer, Denise A Marston, Anthony R Fooks, Dirk Höper, Conrad M Freuling
• Journal: Advances in virus research (Adv Virus Res) Vol. 112 Pg. 115-173 ( 2022) ISSN: 1557-8399 [Electronic] United States
• PMID: 35840180 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Rabies Vaccines

Topics

• Animals
• Animals, Wild
• Antelopes (physiology)
• Rabies (epidemiology, prevention & control, veterinary)
• Rabies Vaccines
• Rabies virus (genetics)