International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches.

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality and disability in developed countries. According to WHO, an estimated 17.9 million people died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to major adverse cardiac and cerebral events. Early detection and care for individuals at high risk could save lives, alleviate suffering, and diminish economic burden associated with these diseases. Carotid artery disease is not only a well-established risk factor for ischemic stroke, contributing to 10%-20% of strokes or transient ischemic attacks (TIAs), but it is also a surrogate marker of generalized atherosclerosis and a predictor of cardiovascular events. In addition to diligent history, physical examination, and laboratory detection of metabolic abnormalities leading to vascular changes, imaging of carotid arteries adds very important information in assessing stroke and overall cardiovascular risk. Spanning from carotid intima-media thickness (IMT) measurements in arteriopathy to plaque burden, morphology and biology in more advanced disease, imaging of carotid arteries could help not only in stroke prevention but also in ameliorating cardiovascular events in other territories (e.g. in the coronary arteries). While ultrasound is the most widely available and affordable imaging methods, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), their combination and other more sophisticated methods have introduced novel concepts in detection of carotid plaque characteristics and risk assessment of stroke and other cardiovascular events. However, in addition to robust progress in usage of these methods, all of them have limitations which should be taken into account. The main purpose of this consensus document is to discuss pros but also cons in clinical, epidemiological and research use of all these techniques.

• Authors: Luca Saba, Pier Luigi Antignani, Ajay Gupta, Riccardo Cau, Kosmas I Paraskevas, Pavel Poredos, Bruce Wasserman, Hooman Kamel, Efthymios D Avgerinos, Rodrigo Salgado, Federico Caobelli, Leonardo Aluigi, Luis Savastano, Martin Brown, Tom Hatsukami, Emad Hussein, Jasjit S Suri, Armado Mansilha, Max Wintermark, Daniel Staub, Jose Fernandes Montequin, Ruben Tomas Toro Rodriguez, Niranjan Balu, Jan Pitha, M Eline Kooi, Brajesh K Lal, J David Spence, Giuseppe Lanzino, Hugh Stephen Marcus, Marcello Mancini, Seemant Chaturvedi, Ales Blinc
• Journal: Atherosclerosis (Atherosclerosis) Vol. 354 Pg. 23-40 (08 2022) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 35816927 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Topics

• Atherosclerosis (pathology)
• Cardiology
• Carotid Arteries (diagnostic imaging, pathology)
• Carotid Artery Diseases (complications, diagnostic imaging, therapy)
• Carotid Intima-Media Thickness
• Consensus
• Humans
• Plaque, Atherosclerotic (complications)
• Positron-Emission Tomography
• Risk Factors
• Stroke (diagnostic imaging, etiology, prevention & control)