Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis.

Abstract

Circulating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (IL)-17 may be helpful in HBV spontaneous clearance [odds ratio (OR) = 1.468, 95%confidence interval (CI) = 1.080-1.995, P = 0.014] and protective against HBV-related hepatoma development (OR = 0.933, 95%CI = 0.910-0.957, P < 0.001). IL-1β negatively affected HBV clearance (OR = 0.052, 95%CI = 0.005-0.534, P = 0.013). In patients with chronic hepatitis B, interferon-γ-inducible protein-10 (IP-10) levels significantly increased in the group of abnormal liver function (P = 0.006). Furthermore, positive correlations of IP-10 with alanine aminotransferase and aspartate aminotransferase levels were observed (r s = 0.546 and 0.644, respectively; P < 0.001). In conclusion, inflammatory cytokines and chemokines may be a "double-edged sword" for HBV clearance and progression. Further exploration of the roles of IL-17, IL-1β, and IP-10 in chronic HBV infection is needed.

• Authors: Zhenzhen Su, Jie Chen, Junlong Zhang, Yunfei An, Yun Liao, Xiaojuan Wu, Chuanmin Tao, Lanlan Wang, Bei Cai
• Journal: Journal of immunology research (J Immunol Res) Vol. 2022 Pg. 5202898 ( 2022) ISSN: 2314-7156 [Electronic] Egypt
• PMID: 35785033 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Zhenzhen Su et al.

Chemical References

• CXCL10 protein, human
• Chemokine CXCL10
• Cytokines
• IL1B protein, human
• Interleukin-17
• Interleukin-1beta

Topics

• Chemokine CXCL10
• Cytokines
• Hepatitis B
• Hepatitis B virus
• Hepatitis B, Chronic (diagnosis)
• Humans
• Interleukin-17
• Interleukin-1beta
• Prognosis