Abstract |
Drug hypersensitivity can be an important problem during pharmacological management of various diseases. Patients diagnosed as having a drug allergy usually need to avoid the offending drug, either temporarily or for life. Another way of overcoming a drug allergy is to establish desensitization using the allergen drug itself. We previously investigated in vitro desensitization of human basophils using a subthreshold dose of an IgE- crosslinking reagent. We found that basophil desensitization occurred in a dose-dependent manner over a period of one to several hours. We think that inducible basophil desensitization occurring without histamine release may explain, at least in part, the clinical features of drug desensitization in type 1 drug allergy.
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Authors | Masao Yamaguchi, Akiko Komiya, Maho Suzukawa, Rikiya Koketsu, Risa Shiragami, Motoyasu Iikura, Hiroyuki Nagase |
Journal | Frontiers in allergy
(Front Allergy)
Vol. 3
Pg. 874772
( 2022)
ISSN: 2673-6101 [Electronic] Switzerland |
PMID | 35769573
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Yamaguchi, Komiya, Suzukawa, Koketsu, Shiragami, Iikura and Nagase. |