Successful recanalization of completely obstructed portal vein thrombosis after right hepatectomy for perihilar cholangiocarcinoma by aspiration thrombectomy via the ileocolic mesenteric vein and subsequent systemic anticoagulation with edoxaban.

Abstract

Portal vein thrombosis (PVT) is a lethal complication of hepatectomy if not properly treated. An 81-year-old woman diagnosed with postoperative PVT after right hepatectomy and caudate lobectomy for perihilar cholangiocarcinoma. Elevation of serum total bilirubin levels, D-dimer levels, and glossy ascites appeared on postoperative day 5 (POD5), and a contrast-enhanced CT confirmed PVT. Thrombi were found from the umbilical portion of the portal vein to the superior mesenteric vein. There were signs of acute liver failure due to thrombi obstructing the portal vein. Therefore, emergent catheter thrombus aspiration was performed under laparotomy. An aspiration catheter was inserted into the superior mesenteric vein from the ileocolic vein. We performed direct aspiration thrombectomy, followed by anticoagulant administration using urokinase via the catheter. Partial recanalization of the portal vein and superior mesenteric vein was observed. To dissolve residual thrombi, edoxaban administration was started on POD6. Contrast-enhanced CT 16 days after her additional operation showed the thrombi had completely disappeared. The patient was discharged on POD76. She had no recurrence of PVT over the next 6 months. Combination therapy of early intervention using aspiration catheter and systemic anticoagulant medication was useful for severe postoperative PVT accompanied with liver failure.

• Authors: Hidetoshi Gon, Daisuke Tsugawa, Hiroaki Yanagimoto, Eisuke Ueshima, Takuya Mizumoto, Shinichi So, Hirochika Toyama, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto
• Journal: Clinical journal of gastroenterology (Clin J Gastroenterol) Vol. 15 Issue 5 Pg. 981-987 (Oct 2022) ISSN: 1865-7265 [Electronic] Japan
• PMID: 35768758 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2022. Japanese Society of Gastroenterology.

Chemical References

• Anticoagulants
• Pyridines
• Thiazoles
• Urokinase-Type Plasminogen Activator
• edoxaban
• Bilirubin

Topics

• Aged, 80 and over
• Anticoagulants (therapeutic use)
• Bile Duct Neoplasms (complications, drug therapy, surgery)
• Bilirubin (therapeutic use)
• Female
• Hepatectomy (adverse effects)
• Humans
• Klatskin Tumor
• Liver Diseases (complications)
• Mesenteric Veins (surgery)
• Portal Vein
• Pyridines
• Thiazoles
• Thrombectomy (adverse effects)
• Thrombosis (surgery)
• Urokinase-Type Plasminogen Activator (therapeutic use)
• Venous Thrombosis (drug therapy, etiology, surgery)