Rational design of a meso phosphate-substituted pyronin as a type I photosensitizer for photodynamic therapy.

Abstract

Type I photodynamic therapy (PDT) with less oxygen consumption shows great potential to overcome the malignant hypoxia in solid tumors. Herein, a novel meso phosphate-substituted pyronin PY-P and its nanoparticles (PY-P NPs) were prepared as an efficient type I organic photosensitizer. The in vivo data prove that PY-P NPs have outstanding low dark toxicity but high photocytotoxicity under hypoxia (<1% O2).

• Authors: Yong Wang, Jigai Li, Yukun Zhang, Yi Nan, Xin Zhou
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 58 Issue 56 Pg. 7797-7800 (Jul 12 2022) ISSN: 1364-548X [Electronic] England
• PMID: 35735141 (Publication Type: Journal Article)

Chemical References

• Phosphates
• Photosensitizing Agents
• Pyronine

Topics

• Cell Line, Tumor
• Humans
• Hypoxia
• Nanoparticles
• Phosphates
• Photochemotherapy
• Photosensitizing Agents (pharmacology)
• Pyronine