Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD.
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| Abstract |
COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of cigarette smokers developing COPD from cigarette smoke (CS)-induced irreversible damage and sustained inflammation of the airway epithelium. Inflammasome activation leads to the cleavage of pro-interleukin (IL)-1β and pro-IL-18, along with the release of pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase pro-inflammatory responses and concurrent pyroptosis. There is currently intense interest in the role of nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes in chronic inflammatory lung diseases such as COPD and their potential for therapeutic targeting. Phytochemicals including polyphenols and flavonoids have phyto-medicinal benefits in CS-COPD. Here, we review published articles from the last decade regarding the known associations between inflammasome-mediated responses and ameliorations in pre-clinical manifestations of CS-COPD via polyphenol and flavonoid treatment, with a focus on the underlying mechanistic insights. This article will potentially assist the development of drugs for the prevention and therapy of COPD, particularly in cigarette smokers.
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| Authors | Yaw-Syan Fu, Ning Kang, Yanping Yu, Yan Mi, Jialin Guo, Jingyi Wu, Ching-Feng Weng |
| Journal | European respiratory review : an official journal of the European Respiratory Society (Eur Respir Rev) Vol. 31 Issue 164 (Jun 30 2022) ISSN: 1600-0617 [Electronic] England |
| PMID | 35705209 (Publication Type: Journal Article, Review) |
| Copyright | Copyright ©The authors 2022. |
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