The complexity, and the diversity of the different types of
cancers allied to the tendency to form
metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie
carcinogenesis and
metastasis. The development of more selective
therapies made it possible to improve
cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey.
RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in
cancer, and there are already some
RNA-based formulations in clinical trials. However, the use of
RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate
RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of
RNA and
RNA-associated
therapies to fight
cancer, also providing, as support, a general overview of nanoplatforms for
RNA delivery.