Abstract | OBJECTIVE: METHODS: This study included 28,476 patients diagnosed with CHD. Their lipid levels, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol ( LDL-C), were measured, and non-traditional lipid parameters were calculated. The patients were divided into three groups based on the diabetic status including normoglycemic (NG), pre-DM, and T2DM. Multiple logistic regression was used to compare the association of TG/HDL-C and other non-traditional lipid parameters with pre-DM and T2DM. The tertiles of TG/HDL-C included T1 (TG/HDL-C < 1.10), T2 (1.10 ≤ TG/HDL-C ≤ 1.89) and T3 (TG/HDL-C > 1.89). Low and high TG/HDL-C was defined with sex-specific cutoff points. RESULTS: Multiple logistic regression results showed that the non-traditional lipid parameters, including non-HDL-C, LDL-C/HDL-C, TC/HDL-C, non-HDL-C/HDL-C and TG/HDL-C, were all correlated with the risk of pre-DM and T2DM. Meanwhile TG/HDL-C showed the strongest correlation (odds ratio [OR]: 1.19; 95% confidence interval [CI] 1.16-1.23), (OR: 1.36; 95% CI 1.33-1.39). When dividing TG/HDL-C into tertiles, using T1 as a reference, T3 was observed to have the highest association with both pre-DM and T2DM (OR: 1.60; 95% CI 1.48-1.74), (OR: 2.79; 95% CI 2.60-3.00). High TG/HDL-C was significantly associated with pre-DM and T2DM (OR: 1.69; 95% CI 1.52-1.88), (OR: 2.85; 95% CI 2.60-3.12). The association of TG/HDL-C with T2DM and pre-DM existed across different sex, age, smoking, and drinking statuses. CONCLUSION: Elevated non-traditional lipid parameters were significantly associated with pre-DM and T2DM in CHD patients, especially TG/HDL-C. High TG/HDL-C was the risk factor with a strong correlation with the risk of pre-DM and T2DM.
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Authors | Tong Yang, Yijia Liu, Lin Li, Yanchao Zheng, Yang Wang, Jinyu Su, Rongrong Yang, Mingchi Luo, Chunquan Yu |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 21
Issue 1
Pg. 93
(06 03 2022)
ISSN: 1475-2840 [Electronic] England |
PMID | 35659300
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Cholesterol
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Topics |
- Cholesterol
- Cholesterol, HDL
- Cholesterol, LDL
- Coronary Disease
(complications, diagnosis, epidemiology)
- Diabetes Mellitus, Type 2
(complications, diagnosis, epidemiology)
- Female
- Humans
- Male
- Prediabetic State
(complications, diagnosis, epidemiology)
- Risk Factors
- Triglycerides
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