Triple-negative breast cancer (TNBC) is considered one of the un-manageable types of
breast cancer, involving devoid of
estrogen,
progesterone, and
human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and
metastasis, the management of TNBC remains a mainstay challenge, despite the advancements in
cancer therapies. Conventional
chemotherapy remains the only treatment regimen against TNBC and suffers several limitations such as low bioavailability, systemic toxicity, less targetability, and multi-drug resistance. Although various targeted
therapies have been introduced to manage the hardship of TNBC, they still experience certain limitations associated with the survival benefits. The current research thus aimed at developing and improving the strategies for effective
therapy against TNBC. Such strategies involved the emergence of nanoparticles. Nanoparticles are designated as nanocavalries, loaded with various agents (drugs, genes, etc.) to battle the progression and
metastasis of TNBC along with overcoming the limitations experienced by conventional
chemotherapy and targeted
therapy. This article documents the treatment regimens of TNBC along with their efficacy towards different subtypes of TNBC, and the various nanotechnologies employed to increase the therapeutic outcome of FDA-approved drug regimens.