Current Understanding of Long-Term Cognitive Impairment After Sepsis.

Abstract

Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a dysregulated host response to infection. Although the incidence and mortality of sepsis decrease significantly due to timely implementation of anti-infective and support therapies, accumulating evidence suggests that a great proportion of survivors suffer from long-term cognitive impairment after hospital discharge, leading to decreased life quality and substantial caregiving burdens for family members. Several mechanisms have been proposed for long-term cognitive impairment after sepsis, which are not mutually exclusive, including blood-brain barrier disruption, neuroinflammation, neurotransmitter dysfunction, and neuronal loss. Targeting these critical processes might be effective in preventing and treating long-term cognitive impairment. However, future in-depth studies are required to facilitate preventive and/or treatment strategies for long-term cognitive impairment after sepsis.

• Authors: Ying Li, Muhuo Ji, Jianjun Yang
• Journal: Frontiers in immunology (Front Immunol) Vol. 13 Pg. 855006 ( 2022) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 35603184 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Li, Ji and Yang.

Topics

• Cognitive Dysfunction (etiology)
• Humans
• Quality of Life
• Sepsis (complications)
• Survivors