Fuzhuan brick tea polysaccharides serve as a promising candidate for remodeling the gut microbiota from colitis subjects in vitro: Fermentation characteristic and anti-inflammatory activity.

Abstract

The purified fraction 3 of polysaccharides from Fuzhuan brick tea (FBTPS-3) could attenuate the colitis and modulate the gut microbiota. However, the relationship between anti-inflammatory effect of FBTPS-3 and the gut microbiota is still unknown. Thus, the anaerobic fermentation in vitro was used to investigate the potential mechanism. FBTPS-3 could be utilized and degraded by gut microbiota from inflammatory bowel disease (IBD) subjects. Furthermore, FBTPS-3 could modulate the composition and structure of IBD gut microbiota toward to that of healthy group. FBTPS-3 showed a superior modulated effect on IBD gut microbiota by increasing Bacteroides and decreasing Escherichia/Shigella. Furthermore, the fermentation solution rather than FBTPS-3 itself showed anti-inflammatory effects on lipopolysaccharide-treated RAW264.7 macrophages, which might be due to the metabolites such as short-chain fatty acids (SCFAs). Thus, FBTPS-3 can be expected as novel prebiotics for treatment of IBD via modulating gut microbiota, and promoting the production of SCFAs.

• Authors: Guijie Chen, Mingjia Wang, Ziqi Zeng, Minhao Xie, Weiqi Xu, Yujia Peng, Wangting Zhou, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
• Journal: Food chemistry (Food Chem) Vol. 391 Pg. 133203 (Oct 15 2022) ISSN: 1873-7072 [Electronic] England
• PMID: 35597036 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Fatty Acids, Volatile
• Polysaccharides
• Tea

Topics

• Anti-Inflammatory Agents (pharmacology)
• Colitis (chemically induced, drug therapy)
• Fatty Acids, Volatile (metabolism)
• Fermentation
• Gastrointestinal Microbiome
• Humans
• Inflammatory Bowel Diseases (drug therapy)
• Polysaccharides (chemistry, pharmacology)
• Tea (chemistry)