Some previous studies have shown that PLOD2 has some value in
tumorigenesis. However, the broad significance of PLOD2 has not been discussed in depth. This study was aimed at elaborated and summarized the value of PLOD2 in various
tumors. First, we integrated GTEx, The
Cancer Genome Atlas and
Cancer Cell Line Encyclopedia databases to analyze the expression of PLOD2, and found that it was expressed differently in normal tissues and significantly highly expressed in most
tumors compared with normal tissues. Second, our analysis revealed that PLOD2 expression was negatively correlated with the prognosis of several
tumors. For
gastric cancer, the median overall survival time was significantly higher in the PLOD2 low expression group [HR 0.616 (95%CI 0.442-0.858), p = 0.004]. Third, for
tumor immunity, PLOD2 was significantly associated with
tumor infiltration, including immune infiltrating cells; immune checkpoint expression; immune microenvironment scores (immune score, stromal score and estimate scores);
immunotherapy-related scores (
tumor mutational burden,
microsatellite instability,
tumor neoantigen burden); expression of DNA repair genes Mismatch Repairs and
methyltransferase; and enrichment analyses identified PLOD2-associated terms and pathways. Lastly, twenty pairs of
gastric cancer and adjacent immunohistochemistry showed that PLOD2 was significantly overexpressed in
gastric cancer (p < 0.001). Collectively, PLOD2 played a significant role in
tumorigenesis and maybe serve as a potential
biomarker for diagnosis and prognosis in
cancers.